3M Biopharmaceutical Technical Education: Join Our Webinar Series
Join 3M experts for a series of free technical webinars on advanced cell culture harvest processes using depth filters and chromatographic clarification technologies. This series of courses will help you understand:
- Technical models of filtration
- Designing robust filtration processes
- Optimizing filtration train that results in efficient downstream operations
- Mitigation of cell shear
- Dealing with problematic host cell proteins
- Improving ‘Protein A’ performance in continuous capture operations
Ready to get the webinar(s) on your calendar?
Register now! Click to register for each webinar you want to attend.
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Filtration Fundamentals: Clarification & Sterilization for the Manufacture of Recombinant Proteins
In Ethan’s two-part webinar series on the fundamentals of filtration, he marries a rigorous theoretical treatment of mass transport phenomena with practical application to clarification and sterilization processes used at biopharmaceutical companies every day. Based on his lectures at the Massachusetts Institute of Technology, Ethan starts with a broad overview of filtration terminology and then delves deeply into structure-function relationships, phenomenological modelling, bench-scale analysis and process-scale sizing. These webinars are intended for new and experienced process development scientists alike and will set the foundation for advanced topics discussed in later webinars.
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Chromatographic Clarification: Functionalized Nonwovens and their Application to Recombinant Protein Manufacturing
During the production of recombinant proteins, cell culture fluid clarification has traditionally targeted the removal of large, insoluble species such as host cells and their associated debris. Conventional bead-based chromatography rapidly fouls when implemented in this stage. In contrast, recently commercialized functionalized nonwoven technologies have demonstrated robust impurity removal during cell culture fluid clarification. This webinar details the key attributes of a functionalized nonwoven technology and its application to biopharmaceutical purification. Case studies comparing clarification using a nonwoven functionalized with a quaternary amine and traditional depth filtration are also explored to demonstrate the benefits of adopting chromatographic clarification.
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Advanced Clarification Strategies to Mitigate Cell Shear
Mammalian cell culture continues to be the workhorse for the expression of high-value therapeutic recombinant protein modalities. As requirements for manufacturing process performance, product quality and process safety become more stringent, cell shear during clarification has become a critical consideration for both preventing product degradation and designing clarification processes. In this webinar, Masa will present on cell shear mechanisms during clarification, the impact of cell shear on product quality and strategies to mitigate cell shear in depth filtration.
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Chromatographic Clarification
In Hani’s two-part webinar series, he will share data from recent research collaborations with University College London (UCL) and The National Institute of Bioprocessing Research and Training (NIBRT), exploring the impact of applying flow-through chromatography with nonwovens on clearance of soluble impurities, particularly Host Cell DNA. The research begins by investigating the impact of DNA removal prior to Protein A chromatography on the clearance of key problematic host cell proteins tracked using sophisticated LC-MS techniques. It will then show how DNA clearance during clarification can enhance the performance of Continuous Protein A Capture Chromatography. Building on the earlier webinars, these webinars are intended for new and experienced Process Development Scientists alike.
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