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Explore our lab scale
solutions.

Simplify the development process for your whole team. From clarification of cell cultures to making bioprocessing more efficient, our scalable lab devices allow you to hand off a scalable process that delivers consistent results while saving time and money.

Chromatographic solutions for a consistent clarification and purification process.

Our single-use clarification and purification products are designed to address yield and removal of process-related impurities using proprietary technologies that are helping advance the biopharmaceutical manufacturing industry. We offer scalable solutions for harvest and clarification as well as purification.

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    Predictable Scalability

    Our portfolio offers linear scalability from lab to commercial production.

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    An easy way to try new technology

    Easily access and try a variety of solutions on a smaller scale before making a large investment.

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    A wide range of benefits

    Our scalable lab devices address customer challenges and help deliver results such as simplified processes and enhanced product recovery.

Want to try a scalable lab device?

Our devices are an easy way to test new technology. Our experts are happy to help you find the appropriate scalable device for your unique needs.

  • Product image of harvest rc bc4 wbox

    3M™ Harvest RC Chromatographic Clarifier

    This portfolio of single-stage, single-use encapsulated chromatographic clarification solutions is used for direct harvest and clarification processes.

    Performance:

    • High mAb product recovery (>95%)
    • Reduction of DNA below 500ppb
    • Synthetic fibrous anion exchange (AEX) chromatography
    Applications include: Direct harvest in a single stage, replacement of primary and 2nd depth filters and guard filters, replacement of centrifuge.

    Learn more about our solution

    Explore more details of 3M™ Harvest RC Chromatographic Clarifier



  • Product image of 3m emphaze aex hybrid purifier

    3M™ Emphaze™ AEX Hybrid Purifier

    Reduce clarification impurities with this versatile and scalable chromatographic purification device.

    Performance:

    • 20-40% HCP reduction and greater than 4 logs DNA reduction
    • Consistent output turbidity (<5NTU)
    • Typically, ≥ 4LRV endotoxin reduction at low conductivity and neutral pH depending on buffer
    Applications include: Replacement of secondary depth filters in harvest and clarification, guard filter to protein A and bioburden control.

    Learn more about our solution

    Explore more details of 3M™ Emphaze™ AEX Hybrid Purifier



  • Product image of 3m polisher st

    3M™ Polisher ST

    Remove impurities in the presence of turbidity with this single-use anion exchange (AEX) polishing chromatography that performs in a wide range of process conditions.

    Performance:

    • HCP reduction >50%
    • Virus clearance >4 logs
    • High mAb recovery >95%
    Applications include: Replacement of AEX column and Replacement of depth filter and membrane filter prior to AEX column.

    Learn more about our solution

    Explore more details of 3M™ Polisher ST



Science for the unique needs of the discovery phase. Learn more

Streamline your workflow in the discovery phase with our lineup of lab scaling products, including 3M™ Harvest RC Chromatographic Clarifier, WP6; 3M™ Harvest RC Chromatographic Clarifier, CT15 and 3M™ Harvest RC Chromatographic Clarifier, BT500.

Depth Filtration—A core bioprocessing filtration solution.

Depth filters use cellulose based filtration medium with filter aids to retain particles throughout the media, rather than just on the media surface. High-performance filter media combined with proper media selection and sizing can provide excellent throughput performance and filtration efficiency.

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    Impurity filtration through a variety of mechanisms

    Unlike other types of filters, depth filtration captures particles through various mechanisms including direct interception, inertia impaction and electrostatic adsorption.

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    Large volume particulate removal

    Depth filters are commonly used when process fluid contains a high particle load because, relative to other types of filters, they can retain a large mass of particles before becoming clogged.

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    Lower cost and increased lifespan

    When compared to membrane filters, depth filters achieve filtration targets with fewer filters (lower filtration surface area) due to their longer filter life, resulting in lower cost for a given process step.

  • Product image of 3M Zeta Plus Depth Filters

    3M™ Zeta Plus™ Depth Filters

    This wide range of pharmaceutical-grade, single-use depth filters provides clarification solutions for a variety of biological and chemical pharmaceutical applications.

    Performance:

    • Variety in nominal pore sizes, charges, and media characteristics
    • Single- and dual-layer formats (select grades)
    • Activated carbon or lipid-removal media series also available
    Applications include: Biopharmaceutical processing applications of aqueous and chemical based pharmaceuticals (drugs) and vaccines.

    Learn more about our solution

    Explore more details of 3M™ Zeta Plus™ Depth Filters




Want to try a scalable lab device?

Our devices are an easy way to test new technology. Our experts are happy to help you find the appropriate scalable device for your unique needs.



  • What is fiber chromatography?
    Fiber chromatography is one of the chromatography methods which utilize fibrous matrix as chromatographic media. Due to larger porous structure of fibrous media, fiber chromatography can process significantly larger biological targets, such as cells, micelles, virus and chromatic DNA, which are too large for traditional chromatographic media like chromatographic beads and chromatographic membrane. Also, binding is predominantly convection-driven, enabling a fast processing rate.
  • Can fiber chromatography be used in harvest and clarification?
    Yes. Fiber chromatography can be used in harvest and clarification and offer many benefits including high mAb recovery (>95%), consistent high quality of clarified fluid and linear scalability from lab to pilot to manufacturing.
  • How does depth filtration work?
    Depth filtration utilizes the thickness, or depth, of the filter media to trap insoluble suspended particles, separating them from the process fluid that passes through the media. Particles are captured by various mechanisms through the tortuous or complex path of the media, including direct interception, inertia impaction and electrostatic adsorption.
  • What is the difference between depth filtration and chromatographic clarification?
    Depth filtration removes contaminants primarily by size, while chromatographic clarification removes contaminants by charge. For direct clarification of harvested cell culture fluid, depth filtration typically needs two- stage (primary and secondary depth filters), while chromatographic clarification is one-stage.
  • What are the primary materials used to make a depth filter?
    Depth filters are comprised typically of three components: cellulose, a filter aid, and a polymer binder resin. The material can also be functionalized to contain additional functional chemistry for enhanced performance.
  • Can fiber chromatography replace a depth filter upstream?
    Yes. Fiber chromatography can be used for harvest and clarification instead of depth filtration.
  • What are the benefits of 3M™ Polisher ST in the downstream purification space?
    Benefits of 3M™ Polisher ST include a smaller footprint, higher loading capacities, less buffer usage and no need to pack/repack/validate.
  • Can a single-use 3M™ Polisher ST replace an AEX column?
    Yes. Modern chromatographic membranes such as 3M™ Polisher ST have been shown to be robust and scalable from the bench up to production scales. This allows for a single-use chromatographic device to replace a large multi-use column, saving space and buffers.

    Potential Scalable Device Questions – additional Solventum support needed
  • How do I choose the best products for my application?
    Our Bioprocess Application Specialists will work bench-to-bench with you to help you select the right solution for your complex manufacturing challenges.
  • At what point in my process development is it best to engage with a Solventum expert?
    Working with you every step of the way, our Bioprocess Application Specialists offer continuity of support — completely complementary to your organization. From technical lunch-and-learns to lab trials and demos, we can help you take your breakthrough from discovery to commercialization.

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