3M+KCI Advanced Wound Care Solutions

PROMOGRAN™ Protease Modulating Matrix and PROMOGRAN PRISMA™ Wound Balancing Matrix


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    PROMOGRAN™ Protease Modulating Matrix and PROMOGRAN PRISMA™ Wound Balancing Matrix

    • An advanced, topical treatment for chronic wounds.
    • Clinically proven to improve healing of chronic wounds if used earlier in the treatment regime1.
    • Start using now and give your patients the best chance.

    Chronic wounds can be stalled in the inflammatory phase that may lead to delayed healing2.

    Optimum wound healing environment

    PROMOGRAN™ Matrix and PROMOGRAN PRISMA™ Matrix maintain an optimal wound healing environment.


    • Reduces MMPs3*
    • Cell growth4*
    • Reducing protease activity3*
    • Controlling bacterial growth5*
    • Haemostatic properties4*

    Clinically proven healing power in patients

  • 8.5 times more likely to heal wounds6

  • 52% increase in healing rate with early treatment of VLUs1

  • 90% pressure injuries completely healed7

  • 69% Reduction in Hospital Stays7

  • Cost effective treatment8,9


  • References:

    1. Cullen B, Gibson M, Nisbet L. Early adoption of collagen/ORC therapies improves clinical outcomes. Poster presented at: World Union of Wound Healing Societies (WUWHS); 2012; Japan
    2. Fletcher J, Chadwick P 2019 Identifying and managing inflammation Wounds UK Made Easy. London.
    3. Gibson M, Cullen B. Can natural materials be adapted to optimize their efficacy in wound care? Poster presented at: Society of Advanced Wound Healing (SAWC); 2014; Orlando, FL.
    4. Cullen B Underlying biochemistry in non-healing wounds perpetuates chronicity. Wounds International. 2016; 7(4): 18-24.
    5. Cullen B, Boyle C, Rennison T, Webb Y, Gregory S. ORC/Collagen Matrix Containing Silver Controls Bacterial Bioburden while Retaining Dermal Cell Viability. Poster Presented at WUWHS July 9, 2004; Paris France
    6. Lazaro-Martinez JL, Garcia-Morales E, Beneit-Montesinos JV, Martinez-de-Jesus F, Aragon-Sanchez FJ. Randomized comparative trial of a collagen/oxidized regenerated cellulose dressing in the treatment of neuropathic diabetic foot ulcers. Cir Esp. 2007;82(1):27–31.
    7. Nisi G, Brandi C, Grimaldi L, Calabro M, D’Aniello C. Use of a protease-modulating matrix in the treatment of pressure sores. Chir Ital. 2005;57(4):465–8.
    8. Guest JF, Rana K, Singh H, Vowden P. Cost-effectiveness of using a collagen-containing dressing plus compression therapy in non-healing venous leg ulcers. J Wound Care. 2018;27(2):68-78. doi:10.12968/jowc.2018.27.2.68
    9. Snyder RJ, Richter D, Hill ME. A Retrospective Study of Sequential Therapy with Advanced Wound Care Products versus Saline Gauze Dressings: Comparing Healing and Cost. Ostomy Wound Manage. 2010;56(11A):9–15.

    *As demonstrated in vitro

    Products described on this website (and associated product information), may not be available for sale in all markets as a result of local regulatory requirements. For information regarding product availability in your market, please contact your local 3M+KCI representative.


The brands listed above are trademarks of 3M.