Summary

Date:
Wednesday July 19th 2023

Time:
11 am CEST / 10 am BST

Speaker:
Joris Van de Velde

Event language:
English

In this webinar we will specifically cover:

• An introduction to viral clearance
• Viral clearance using AEX chromatography
• Optimization of process parameters for viral clearance
• Troubleshooting unexpected results

Downstream bioprocessing aims at purifying the product of interest and removing different types of impurities, to deliver a safe and efficacious biologic drug. A very important group of impurities that need to be cleared and validated are viruses. Viral clearance strategies typically consist of multiple orthogonal steps that need to clear or inactivate both enveloped and non-enveloped viruses. Since most viruses are negatively charged under typical process conditions, anion exchange (AEX) chromatography is often utilized as one of the viral clearance steps. This mode of chromatography can be performed by resin-based columns or single use membrane-based technology. Different types of AEX ligands can be considered and process conditions need to be optimized to achieve the best possible performance.

Joris Van de Velde, M.S., is a Bioprocess Applications Specialist at 3M’s Separation and Purification Sciences division. Joris brings 8+ years of experience in depth filtration and chromatographic technologies. He has been working with customers in different global locations, including Belgium, the Netherlands, and USA (Boston and Bay Area). Joris holds a Master of Science in Chemical Engineering from KU Leuven University and a postgraduate degree in Marketing Management from EHSAL Management School in Belgium.

3M School of Purification

The 3M School of Purification is a program designed by a team of 3M Technical Experts, with the purpose of educating the industry on a range of important biopharmaceutical separation and purification topics through a series of interactive and engaging webinars. To learn more about 3M School of Purification and to view all previous webinars On-Demand, visit our website www.3m.co.uk/schoolofpurification.